WebThe proposed mechanism of action for the platinum complexes is that the leaving groups hydrolyze from the central platinum in a process known as aquation, enabling the drug to form intrastrand crosslinks with DNA, thereby inhibiting DNA synthesis. Cisplatin was the first platinum complex to be used clinically but is being replaced by carboplatin. WebAug 1, 1983 · A line of mouse leukemia L1210 cells resistant to cis-diamminedichloroplatinum(II) (cis-DDP) was compared with its parent cell line in order to determine whether the sensitivity difference could be related to DNA interstrand cross-linking as measured by the alkaline elution technique.The study was stimulated by a previous …
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WebApr 15, 2024 · STIGA DNAプラチナXH レビュー. 2024年4月15日. 今回はDNAプラチナXHのレビューとなります。. モーレーゴード選手などプロにも使用され、注目度が高 … WebMar 5, 2024 · Subsequent platinum(II) intercalation into DNA competes with the metal–metal and π–π interactions at the crosslinking points, switching on the spontaneous gel-to-sol transition. In the case of a chloro (2,6-bis(benzimidazol-2′-yl)pyridine)platinum ... unc pulmonology wakefield
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WebThe development of resistance and unwanted harmful interaction with other biomolecules instead of DNA are the major drawbacks for application of platinum (Pt) complexes in … WebA platinum-based anticancer drug is any agent that contains one or more platinum atoms in the oxidation state of II or IV, contains mono- or multidentate non-labile am(m)ine carrier ligands and labile chlorido or bidentate carboxylate ligands, and which acts as a prodrug; it undergoes aquation to yield a reactive complex capable of forming coordinate bonds with … WebApr 15, 2024 · STIGA DNAプラチナXH レビュー. 2024年4月15日. 今回はDNAプラチナXHのレビューとなります。. モーレーゴード選手などプロにも使用され、注目度が高いラバーですが、価格も高いので気軽に試すことが難しいラバーかと思います。. DNAプラチナXHを購入し、実際に3 ... uncp track and field roster