Galactosylated chitosan
WebAug 12, 2024 · In the present study, galactosylated chitosan (Gal-CS) was conjugated with methoxy poly (ethylene glycol) (mPEG) as a hydrophilic group. The structure of Gal-CS-mPEG polymer was characterized and the nanoparticles (NPs) were prepared using ironic gelation method. WebGalactosylated chitosan (GC) has gained increasing attention as a liver-targeted drug carrier in recent years. The present study aimed to investigate the availability of betulinic acid-loaded GC nanoparticles (BA-GC-NPs) for liver protection.
Galactosylated chitosan
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WebMay 1, 2009 · Briefly, 2.2 g of chitosan was dissolved in 50 ml of TEMED/HCl buffer solution (10 m m, pH = 4.7). The carboxyl group of 2.3 g LA was activated with EDC/NHS (molar ratio = 1:1) dissolved in 10 ml of TEMED/HCl buffer solution. EDC was 4-fold molar excess over LA and chitosan/LA was at an equivalent molar ratio. Webgalactosylated chitosan, 5-fluorouracil, mesoporous silica, colon cancer Author for correspondence: Weisan Pan e-mail: [email protected] This article has been edited by …
WebOver several decades, many researchers have reported on the use of primary cells isolated from an animal source for in vitro investigation or pre-clinical studies that describe the addition of growth factors or co-cultivation with other cell types that may enhance DNA synthesis ( 15. , 16. , 17. ). WebChitosan is a naturally occurring polysaccharide obtained by deacetylation of chitin, which is a polycationic polymer comprised of mainly glucosamine units [ 11 ]. It has good biocompatibility, biodegradability, and low toxicity.
WebMar 27, 2024 · Galactosylated chitosan was used in this work, not only to improve the attachment of hepatocytes on the scaffold, but also to ameliorate the mechanical properties of alginate. Indeed, scanning electron microscopy analyses revealed that the porosity and pore size of the sponge were highly dependent on the content and molecular weight of … WebPreparation of Betulinic Acid Galactosylated Chitosan Nanoparticles and Their Effect on Liver Fibrosis . Fulltext; Metrics; Get Permission; Cite this article; Authors Wu ZC, Liu XY , Liu JY , Piao JS, Piao MG . Received 6 May 2024. Accepted for publication 31 August 2024
WebSep 15, 2009 · The resulting galactosylated chitosan (GC) was purified with dialysis and incubated with 3 M excess succinimidyl HYNIC in 0.2 M borate buffer (pH 8.2) for 5 h at room temperature. HYNIC-GC (HGC) was isolated with dialysis.
WebAug 12, 2024 · In the present study, galactosylated chitosan (Gal-CS) was conjugated with methoxy poly (ethylene glycol) (mPEG) as a hydrophilic group. The structure of Gal … jeaune alaska timeWebGalactosylated chitosan-hydroxypropyltrimethylammonium (gal-HTCC) was synthesized by galactosylating and quaternizing chitosan to endue chitosan with targeting specificity for potential applications as gene vectors. The composition and physicochemical properties of gal-HTCC were characterized by FT-IR, 1H NMR, elemental analysis, X-ray ... jea upcoming projectsWebSep 1, 2024 · The use of chemotherapy combined with photothermal therapy (PTT) is getting a focus topic for cancer treatment. Duing this research, the double targeting drug … lad jantung adalah eWebSynthesis, characterization and functional properties of galactosylated derivatives of chitosan through amide formation jeaune tramWebA galactosylated CS (Gal-CS) was also prepared by directly coupling lactobionic acid on CS. Using an iontropic gelation method, CS and the synthesized Gal-CS and Gal-m-CS were used to prepare nanoparticles (CS, Gal-CS, and Gal-m-CS NPs) for targeting hepatoma cells. jea unionWebN2 - Chitosan is a natural polyfunctional polymer that can be modified to achieve compounds with tailored properties for targeting and treating different cancers. In this study, we report the development and anticancer potential of phosphorylated galactosylated chitosan (PGC). jeaunorala djarum