HOTAIR (for HOX transcript antisense RNA) is a human gene located between HOXC11 and HOXC12 on chromosome 12. It is the first example of an RNA expressed on one chromosome that has been found to influence transcription of HOXD cluster posterior genes located on chromosome 2. The … See more The HOTAIR gene contains 6,232 bp and encodes 2.2 kb long noncoding RNA molecule, which controls gene expression. Its source DNA is located within a HOXC gene cluster. It is shuttled from chromosome 12 to … See more The 5′ end of HOTAIR interacts with a Polycomb-group protein Polycomb Repressive Complex 2 (PRC2) and as a result regulates chromatin state. It is required for gene-silencing of the HOXD locus by PRC2. PRC2 is dispensable for HOTAIR-mediated … See more • Page for HOTAIR conserved region 1 at Rfam • Page for HOTAIR conserved region 2 at Rfam See more HOTAIR is highly expressed in metastatic breast cancers. High levels of expression in primary breast tumours are a significant predictor of … See more • Woo CJ, Kingston RE (June 2007). "HOTAIR lifts noncoding RNAs to new levels". Cell. 129 (7): 1257–9. doi:10.1016/j.cell.2007.06.014. PMID 17604716. S2CID 18124576. • Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Rivea Morales D, et … See more WebOct 8, 2013 · The identification of cancer-associated long non-coding RNAs and the investigation of their molecular and biological functions are important for understanding …
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WebLong non-coding RNA HOTAIR has been reported to play a key role in regulating various biological processes in various cancers. However, the roles and mechanisms of HOTAIR in acute myeloid leukaemia (AML) are still unclear and need to be investigated. WebJan 22, 2016 · The importance of HOTAIR in cancer biology has sparked interest in using HOTAIR as a biomarker and potential therapeutic target. Here we show HOTAIR and several tumor-associated lncRNAs are enriched in UEs from UBC patients with high-grade muscle-invasive disease (HGMI pT2-pT4). Knockdown of HOTAIR in UBC cell lines reduces in vitro … grandparent tuition waiver florida
HOTAIR forms an intricate and modular secondary …
WebJan 22, 2016 · The importance of HOTAIR in cancer biology has sparked interest in using HOTAIR as a biomarker and potential therapeutic target. Here we show HOTAIR and … WebJul 26, 2024 · Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for adipocyte development. We find that HOTAIR interacts with polycomb repressive complex 2 (PRC2) and we identify core HOTAIR-PRC2 target genes involved in adipocyte lineage … WebSep 1, 2024 · HOTAIR is a long noncoding RNA (lncRNA) which serves as an important factor regulating diverse processes linked with cancer development. Here, we used … grandparent visitation rights in arizona