Pear1 ipf
WebNov 19, 2024 · Pear1 deficiency in aged mice spontaneously causes alveolar collagens accumulation. Mesenchyme-specific Pear1 deficiency aggravates bleomycin-induced … WebPEAR1 encodes a deduced 1,037-amino acid protein with a molecular mass of 150 kD measured by Western blot. PEAR1 contains a predicted transmembrane domain, an NPXY motif (interaction site for PTB domain-containing proteins), 15 EGF-like repeats in its extracellular domain, and 5 proline-rich domains in its intracellular domain.
Pear1 ipf
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WebSep 22, 2011 · With the use of fine mapping of the PEAR1 locus and sequencing of the PEAR1 gene, we have now identified a common variant (rs12041331, genetic location chromosome 1: 155136338, NCBI build 36.3) in intron 1 of PEAR1 that accounts most strongly for the association signal between the PEAR1 locus and platelet function … WebPEAR1 regulates expansion of activated broblasts and deposition of extracellular matrix in pulmonary brosis Yan Geng 1,8,LinLi1,8,JieYan1,KevinLiu2,AizhenYang3, ... (IPF) 3,4.IPFhas
WebApr 26, 2012 · PEAR1 (platelet endothelial aggregation receptor-1; also known as MEGF12 or JEDI) is a transmembrane protein of the multiple epidermal growth factor (EGF)–like domain protein family, first described in 2005. 1 PEAR1 is mainly expressed in platelets and endothelial cells, as well as satellite glial cell precursors, where it is necessary for … WebJan 31, 2024 · The culture supernatants of LFs from IPF patients, as compared to controls, showed an increase in plasmin activity after plasminogen incubation (5–15 μg/mL), corresponding with increased levels ...
WebAug 2, 2024 · Idiopathic pulmonary fibrosis (IPF) is a lung disorder where there is scarring of the lungs from an unknown cause. It is usually a progressive disease with a poor long … WebPEAR1 regulates fibro- blast activation by associating with Protein Phosphatase 1 to suppress fibrotic factors-induced intracellular signaling. Importantly, mono- clonal …
WebMay 15, 2024 · Introduction: Platelet endothelial aggregation receptor 1 (PEAR1) triggers platelet aggregation and is expressed in platelets and endothelial cells. Genome-wide association studies (GWAS) showed an association between platelet function and single-nucleotide polymorphisms (SNPs) in PEAR1.Methods: In 582 consecutive patients with …
Web mini golf free clip artWebIdiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with an unclear pathogenesis. This study aimed to elucidate the function and potential mechanisms of … most popular mmo in asiaWebAug 18, 2016 · PEAR1 encodes a transmembrane tyrosine kinase receptor expressed in platelets and endothelial cells and plays a role in platelet cell activation. 2 Discovered in 2005, PEAR1 was found to be phosphorylated following platelet aggregation in a proteomic screen. 2 Subsequently, we and others found association of common genetic variants in … mini golf free onlineWebMay 22, 2024 · PEAR1 is a type of receptor tyrosine kinase (RTK) causing platelet- platelet adhesion via the EMI domain (EMILIN Family Domain) in its extracellular part and triggering PI3K/AKT/PTEN signaling, which leads to PEAR1-mediated stimulation of megakaryopoiesis and neoangiogenesis [ 5, 14 ]. most popular mlp shipsWebNov 19, 2024 · PEAR1 belongs to a unique family of EGF (epidermal growth factor) repeat-containing transmembrane proteins 10, and is majorly expressed in endothelial cells and platelets 10 – 13. The high-affinity immunoglobulin E receptor α (FcεR1α) has been identified as a natural ligand for human PEAR1. most popular ml frameworksWebNov 25, 2024 · Platelet endothelial aggregation receptor-1 (PEAR1), expressed in endothelium, platelets, and other tissues, is a platelet transmembrane tyrosine kinase receptor involved in platelet aggregation and platelet-platelet contact. The minor allele (A) in intron 1 of the PEAR1 gene (rs12041331, G>A) is associated with an reduced PEAR1 … most popular mlb playerWebApr 26, 2012 · The recombinant PEAR1 EMI domain (GST-EMI) competitively reduced platelet adhesion to surface-coated PEAR1, diminished platelet aggregation, and … mini golf free online multi player