WebElectrophysiological studies support selectivity of action of phenytoin and lamotrigine on persistent bursts of sodium channel openings, with little effect on normal action potential activity. ... an especially desirable antiarrhythmic drug effect and one that probably contributes to its efficacy for AF. Flecainide prolongs the duration of PR ... WebThe previously successful use of phenytoin to treat serious ventricular arrhythmias led to the investigation for an alternative antiarrhythmic agent, in the same antiarrhythmic drug class, for those patients who develop side effects or become intolerant to phenytoin's antiarrhythmic effect.
Classifications of Antiarrhythmic Agents - Medscape
WebJun 12, 2015 · Phenytoin's narrow therapeutic window, multiple drug interactions and side effect profile make it an infrequently used antiarrhythmic. It is, however, a potent antiarrhythmic agent, which may be useful in treatment of ventricular tachycardia, especially in patients with multiple drug intolerances. 2015 BMJ Publishing Group Ltd. Publication … WebDrug Name Generic Name : phenytoin (diphenylhydantoin, phenytoin sodium) Brand Name: Dilantin-125, Dilantin Infatab, Dilantin Injection, Dilantin Kapseals, Phenytek Classification: Antiepileptic, Antiarrhythmic, group 1b, Hydantoin Pregnancy Category D Dosage & Route Available forms :Chewable tablets—50 mg; oral suspension—125 mg/5 mL; capsules—100 … table column html
Cardiovascular adverse effects of phenytoin SpringerLink
The Vaughan Williams classification was introduced in 1970 by Miles Vaughan Williams. Vaughan Williams was a pharmacology tutor at Hertford College, Oxford. One of his students, Bramah N. Singh, contributed to the development of the classification system. The system is therefore sometimes known as the Singh-Vaughan Williams classification. The five main classes in the Vaughan Williams classification of antiarrhythmic agents are: WebPhenytoin (5,5-diphenylhydantoin), which has been in use for 60 years, is still an important antiepileptic drug. Its primary mechanism of action is modulation of the sustained repetitive firing of neurones by direct inhibition and blockage of voltage-gated sodium channels in the neuronal cell membrane, and by delay of cellular reactivation. WebSep 15, 2024 · Phenytoin (eg, Dilantin) is an anticonvulsant medication used to treat many seizure disorders. It is also a Vaughan-Williams class IB antiarrhythmic agent, although it … table column in python