WebMar 1, 2000 · The antineoplastic drug paclitaxel (Taxol™) is neurotoxic on the peripheral nervous system. Both activity and neurotoxicity of paclitaxel are due to enhancement in tubulin polymerization. In addition, it has been demonstrated that paclitaxel induces gene expression. To elucidate the signal transduction pathways involved in paclitaxel … WebFeb 1, 2024 · Introduction. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of neurotoxic cancer treatment. Estimated to occur …
Effects of Taxol on Regeneration in a Rat Sciatic Nerve ... - Nature
WebFeb 24, 2014 · In contrast to a potential vascular mechanism, other authors have hypothesized that taxane-induced optic nerve dysfunction could also potentially be due to … WebNeurotoxicity, characterized principally by peripheral neurosensory manifestations, ... N2 - Although paclitaxel (TAXOL®) appears to be one of the most promising antineoplastic … clog\\u0027s in
Neurotoxicity of Taxol - PubMed
WebApr 12, 2012 · An allergic reaction also referred to as a hypersensitivity reaction is an overactive or misdirected immune response that results in local tissue injury or changes … WebTaxol appears to be highly effective in those cancers that are ER/PR +, but not nearly as effective for those cancers like uterine papillary serous carcinoma, which is ER/PR-. ... WebMar 1, 2000 · The antineoplastic drug paclitaxel (Taxol™) is neurotoxic on the peripheral nervous system. Both activity and neurotoxicity of paclitaxel are due to enhancement in … clog\\u0027s if