Webb1 jan. 2008 · Ticlopidine also inhibited CYP2D6 (IC 50 of 0.354±0.158μM). In contrast, 2-oxoclopidogrel, prasugrel and R-95913 were much weaker inhibitors of CYP2B6, CYP2C19 and CYP2D6. The inhibitory effects of all the compounds tested were much weaker on the isoforms other than those indicated above. Webb8 mars 2013 · Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of drugs such as bupropion, efavirenz, propofol, and selegiline, among others. More than 200 …
Pitfalls in the design of metabolism-dependent CYP
Webb26 mars 2001 · This invention provides an improved computationally derived regression-based method for determining IC50 or EC50 values for chemical compounds, which predicts potential drug-drug interactions involving cytochrome P450 and other enzymes, transporters, receptors or proteins with active site(s). In addition, this approach predicts … WebbPlasma concentrations of bupropion and its CYP2B6-catalyzed metabolite, hydroxybupropion, were measured for up to 72 hours. RESULTS: The mean area under … ruger 10/22 with sling
Tiklopidin Svensk MeSH
Webb1 mars 2009 · Mechanism-based inhibition of CYP2B6 in human liver microsomes by thienopyridine antiplatelet agents ticlopidine and clopidogrel and the thiolactone … WebbThis study establishes for the first time the specific metabolites of ticlopidine produced by CYP2B6 and CYP2B4, correlates the products with predictions from X-ray … WebbTiclopidine was potent with K(I) and k(inact) values of 0.32 microM and 0.43/min, respectively. The selectivity of these four agents for CYP2B6 was determined by testing their effects on other human P450 enzyme activities using conditions that yield approximately 90% inactivation of CYP2B6 activity. ruger 1 22 full auto conversion instructions